Project: MICNA - Mechanisms of ion conduction in sodium channels

Prace Call: 17th
ID: 2018184455, Leader: Carmen Domene
Affiliation: University of Bath, UK
Research Field: BiochemistryBioinformatics and Life sciences
Collaborators: Simone Furini University of Siena IT
Resource Awarded: 102 Mil. core hours on Piz Daint

Abstract

The transport of ions and water across membrane cells and organelles is a prerequisite for many of life’s processes. Ion channels are proteins that span across the cell membrane allowing the passage of ions from one side of the membrane to the other. Ion channels show ion selectivity, permitting some inorganic ions to pass, but not others, at rates approaching free-diffusion, and they are not continuously open, instead they open and close in response to certain stimuli. Due to the inherent experimental difficulties in obtaining structural data for these systems, it is essential that we maximize our understanding of the structure/function relationships of those membrane proteins for which there is an experimental structure available. As their roles in neurological disorders and diseases in general is prominent, understanding their mechanisms of action and their interactions at atomic level with drugs targets is crucial to develop new treatments.